We're two weeks into the 2022 NFL season, and already we have an idea of which teams might be headed for a serious title run -- none better than the dominant Buffalo Bills. Even so, upsets and comebacks are a weekly ingredient on the NFL schedule. So it's anyone's gue s as to how Week 3 will unfold, especially with a handful of potential playoff previews on the docket. Thankfully, the experts at CBS Sports and SportsLine have Justin Murray Jersey you covered. Each week, we collect all of their best picks and betting advice in one place, so you can get picks against the spread from our experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Time:Sunday, 4:05 p.m. ET (CBS), stream on Paramount+ ( ) Open:Chargers -3, O/U 42.5 Featured Game | Los Angeles Chargers vs. Jacksonville Jaguars Moneyline Spread Total LAC JAC The Jaguars are riding high after blowing out the rival Colts in Week 2, and Trevor Lawrence finally seems to be coming out of his shell as a Doug Pederson disciple. But this feels like "a little bit of a letdown spot," Tyler Sullivan noted on the "Pick Six NFL Podcast" this week. The Chargers are coming off 10 days of rest, Jacksonville is traveling from coast to coast, and L.A. should be motivated to rebound following a tough AFC West lo s in Week 2. Even if Justin Herbert's injured ribs force Chase Daniel under center (and the line inevitably drops), Sully is sold on the Chargers in this spot. For more analysis and Week 3 picks from the "Pick Six" crew, check out the podcast . Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Jaguars at Chargers (-3) Time:Sunday, 4:25 p.m. ET (Fox), stream on fuboTV ( ) Open:Rams -3.5, O/U 48.5 Featured Game | Arizona Cardinals vs. Los Angeles Rams Moneyline Spread Total ARI LAR "The Cardinals have zero busine s sitting at 1-1 right now. Kyler Murray running around like a maniac on fourth down and making miracle plays is simply unsustainable. The Rams are being downgraded publicly because of Week 1's blasting by the Bills and then narrowly squeaking by the Falcons last week. But they took care of busine s against Atlanta before shenanigans happened and Buffalo just might be a buzz saw. The Cardinals are shorthanded at wide receiver Arizona Cardinals T Shirts and the Rams have the sort of superstars to slow down Kyler and limit this pa sing attack." Will Brinson is all over the Rams as big favorites even in a divisional game. Find all of his Week 3 picks . Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Rams (-3.5) at Cardinals Time:Sunday, 4:25 p.m. ET (Fox), stream on fuboTV ( ) Open:Seahawks -1, O/U 42 Featured Game | Seattle Seahawks vs. Atlanta Falcons Moneyline Spread Total SEA ATL "The Falcons have been plucky to begin the season, owning a 2-0 ATS Patrick Peterson T Shirts record. A special teams snafu by the -- a blocked punt returned for a Falcons touchdown -- did bring Atlanta back to life with a cover, but the team still moved the ball well offensively and hasn't even begun to scratch the surface of utilizing star tight end . This week, the Falcons get their easiest opponent of the season thus far in the , despite this game being played on the road at Lumen Field. While Seattle was able to upset the in an emotional opener, and the rest of the offense don't exactly strike fear in opposing defenses. They've also struggled against the run, ranking 28th in the NFL in DVOA." Tyler Sullivan likes the Falcons not only to keep it close against Seattle but beat the Seahawks in their own stadium. You can find all of his Week 3 picks at CBS Sports . Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Falcons at Seahawks (-1) Time:Sunday, 4:25 p.m. ET (Fox), stream on fuboTV ( ) Open:Buccaneers -1, O/U 42 Featured Game | Tampa Bay Buccaneers vs. Green Bay Packers Moneyline Spread Total TB GB Before you lock in any picks for what could be the last-ever Aaron Rodgers-Tom Brady matchup, you'll wanna check in with SportsLine's advanced projection model, which is on a 139-102 run making top-rated NFL picks since 2017. More accurate than 94% of CBS Sports Football Pick'em players four times during that span, the model has reason to trust Brady, even with limited weapons. The agele s QB has two or more Larry Centers Jersey TD pa ses in 13 of his 16 home starts with Tampa Bay, and he's had five straight starts against Green Bay with a pa ser rating of 95 or better. We can tell you the model is leaning Under the total, and one side of this matchup is winning 60% of simulations. Find out which team to back, and more SportsLine analysis on this matchup, . Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Packers at Buccaneers (-1) Time:Sunday, 8:20 p.m. ET (NBC), stream on fuboTV ( ) Open:49ers -1.5, O/U 44 Featured Game | Denver Broncos vs. San Francisco 49ers Moneyline Spread Total DEN SF The 49ers are transitioning at quarterback (again), this time with Jimmy Garoppolo back under center in place of Trey Lance. But Tom Fornelli, who's 17-6 in his picks involving San Francisco, is particularly encouraged by the Niners defense going into Week 3: San Francisco leads the NFL in total defense, giving up 210 yards and only 13 points Jake Plummer Jersey per game. The 49ers also lead the league in first downs allowed and pa sing yards allowed, whereas the Broncos have been sloppy moving the ball. We can tell you Fornelli is leaning Under the total, but to see his ATS pick for Broncos-49ers, . Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg 49ers (-1.5) at Broncos Time:Monday, 8:15 p.m. ET (ESPN), stream on fuboTV ( ) Open:Cowboys -1, O/U 39 Featured Game | New York Giants vs. Dallas Cowboys Moneyline Spread Total NYG DAL Brian Daboll has inspired the New York fan b